陈志龙

发布部门：生物与医学工程学院 发布时间：2022-07-08



陈志龙 二级教授


个人简介：

陈志龙：二级教授、博士生导师、主任药师、国家重点研发计划主持者。

为第二军医大学药学学士、医学博士（药学专业），曾先后在中科院上海有机化学研究所、澳大利亚Central Queensland University、英国The University of Liverpool进行3次博士后研究。曾任第二军医大学防护医学教研室主任。现为东华大学生物与医学工程学院生物医药研究组组长，药物化学与药理学教授，博士生导师。发表论文370余篇。出版英文专著2部、中文专著3部。申请国家发明专利90余项。培养博士后、博士与硕士研究生及留学生140余名。

研究方向:

  1. 人工智能（AI）和计算机辅助（CADD）新药研发；

  2. 光敏新药研发及光动力疗法的基础与应用研究（如抗肿瘤、抗鲜红斑痣、抗菌抗病毒作用等）；

  3. 靶向药物研究（如抗肿瘤靶向新药研究；降压新药研究；多肽、单克隆抗体等靶向分子导向的新药研究）；

  4. 多功能、多模态药物微纳靶向制剂研究；

  5. 中药与天然药物研究；

  6. 药物代谢、药理毒理学及临床药学研究;

  7. 医学成像试剂研究。

荣誉及获奖情况：

  1. 第二军医大学 “学习成才十佳先进个人”；

  2. 上海市“浦江人才”；

  3. 南京市“创新创业人才”；

  4. 上海市“优秀学术技术带头人”；

  5. 嘉兴市“科技领军人才”;

  6. 主持项目“光敏新药与试剂的研制及光动力疗法的基础与应用研究”获上海市药学科技二等奖（2012年）;

  7. 主持项目“光敏新药与试剂的研制及光动力疗法的基础与应用研究”获中国药学科技三等奖（2013年）;

  8. 参与项目（第二负责人）“光动力治疗皮肤病关键技术创新及推广应用”获中华医学科技三等奖（2017年）;

  9. 主持，平湖市创新创业大赛一等奖----光敏新药与试剂及降压新药研究开发（2018年）。

承担的主要科研项目：

承担各类项目100余项，其中主持60余项。如主持各类人才基金5项、国家重点研发计划1项、国家自然科学基金7项、军队医药卫生重大课题1项、上海市科委与教委重点项目7项、科技部与上海市国际合作项目8项等。指导团队成员获国家重点研发计划1项、国家自然基金5项、国家与上海市博士后基金11项、上海市科委重点项目8项等。部分课题如下：

  1. 国家重点研发计划（No. 2025YFE0101400、2026YFE0204500）。

  2. 国家自然科学基金（No. 30271534；29872055；30973611；30070862； 21372042； 21977016；22361132541等）。

  3. 上海市优秀学术技术带头人人才计划基金（No. 15XD1523400）。

  4. 上海市浦江人才计划基金（No. 06PJ14001）。

  5. 上海市科委重点基金（No. 064319020; 10DZ0502300; 13431900700；14140903500； 15411960400；17431902600；21430730100等）。

  6. 科技部与上海市国际科技合作基金（No. 6-11、11BA1400700、13430722300、17430711900、18430713000、20490740400、21430730100、9-33、10-6、25HB2711400等）。

  7. 军队医药卫生重大项目（No. 01L054）。

  8. 上海市教委重点项目基金（No. 10ZZ45）。

  9. 教育部重点项目（No. 108146）。

发表论文：370余篇

近年发表的部分论文：

  1. Yao Yin, Sami Karam, Zhi-Long Chen*, et al. Discovery of novel 1,2,4-triazoles derivatives acting as NF1 activators against cervical cancer. Bioorganic and Medicinal Chemistry, 2026, 138, 118661. (SCI, JCR Q2)

  2. E. V Akhlyustina*, Zhi-Long Chen, I. V Reshetov, et al. Photophysical properties of photosensitizers based on polycationic phthalocyanines and their phototoxicity against breast cancer cells. Optical and Quantum Electronics, 2026, 58, 88, 1-11.   (SCI, JCR Q1)

  3. Ying Jiang, Igor V. Reshetov, Zhi-Long Chen*, et al. The synthesis, photophysical and biological properties of 5,10,15,20-tetra(4-substituted phenyl)tetrabenzoporphyrin derivatives. European Journal of Medicinal Chemistry, 2025, 291, 117612. (SCI, JCR Q1)

  4. Le Mi, Tao Xu, T. Nyokong, Zhi-Long Chen*, et al. Tetracationic tetraaryltetranaphtho[2,3]porphyrins for photodynamic inactivation against Staphylococcus aureus biofilm. European Journal of Medicinal Chemistry, 2025, 290, 117558. (SCI, JCR Q1)

  5. Yingyuan Peng, Sami Karam, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance. European Journal of Medicinal Chemistry, 2025, 282, 117090.  (SCI, JCR Q1)

  6. Ziyu Wang, Yingyuan Peng, Zhilong Chen*, et al. MiRNAbased drugs: Challenges and delivery strategies. Applied Microbiology and Biotechnology, 2025, 109:247. (SCI, JCR Q1)

  7. W.M. Eldehna, R. Elrayess, Zhi-Long Chen, et al. Discovery of novel piperidinyl-based benzoxazole derivatives as anticancer agents targeting VEGFR-2 and c-met kinases. Pharmaceuticals, 2025, 18, 1875. (SCI, JCR Q1).

  8. Mingjie Wang, V. S. Bagnato, T. Nyokong, Zhi Long Chen*, et al. Bis-quaternary ammonium BODIPY derivatives: Photophysical, antimicrobial, and antitumor photodynamic applications. Bioorganic Chemistry, 2025, 165, 108982. (SCI, JCR Q1)

  9. Feng Xiao, S. K. Bussadori, C. E. Palavecino,Zhi-Long Chen*. Synthesis and evaluation of multi-quaternary ammonium cation-functionalized BODIPYs with photodynamic antibacterial effects. Bioorganic Chemistry, 2025, 164,108859. (SCI, JCR Q1)

  10. Hongyu Liang, Yijia Yan, Zhi-Long Chen*, et al. Synthesis of novel meso-tetraphenyltetrabenzoporphyrins and evaluation of their photodynamic anticancer activities. ACS Omega, 2025, 10, 11119-11127. (SCI, JCR Q2)

  11. Anita Benić, Yijia Yan, Zhi-Long Chen*, Davor Margetic*, et al. Significant tumor inhibition of trimethyl-152-[L-aspartyl]pheophorbide a in tumor photodynamic therapy. ChemMedChem, 2025, e202500087 (1 - 10). (SCI, JCR Q2)

  12. Gennady Meerovich, Evgeniya Kogan, Igor Romanishkin*, Zhi-Long Chen, Igor Reshetov, et al Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience. Photodiagnosis and Photodynamic Therapy, 2025, 51, 104447. (SCI, JCR Q3)

  13. Tao Xu, Igor Vladimirovich Reshetov, Evgeniy Altarovna Kogan, Zhi-Long Chen*, et al. Quaternary ammonium cations conjugated 5,15-diaryltetranaphtho [2,3] porphyrins as photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 267, 116228. (SCI, JCR Q1)

  14. Tao Xu, Le Mi, Zhi-Long Chen*, et al. Design, synthesis, and evaluation of 5,15- diaryltetranaphtho [2,3] porphyrins as photosensitizers in real-time photodynamic therapy and photodiagnosis. European Journal of Medicinal Chemistry, 2024, 264, 115980.  (SCI, JCR Q1)

  15. Ning Cao, Zhi-Long Chen*, et al. Synthesis and evaluation of novelmeso-substitutedphenyldithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 264,116012. (SCI, JCR Q1)

  16. Ning Cao, Zhi-Long Chen*, et al. Synthesis and photodynamic activity of novel thieno[3,2–b]thiophene fused BODIPYs with good bio-solubility and anti-aggregation effect. Bioorganic Chemistry, 2024, 143, 107097. (SCI, JCR Q1).

  17. Le Mi, Yi-Jia Yan, I. V. Reshetov, E. A. Kogan, Yomen Atassi, Zhi-Long Chen*. Synthesis and evaluation of 5,15-diaryltetrabenzoporphyrins as photosensitizers for photo-diagnosis and photodynamic activity of tumors. Bioorganic Chemistry, 2024, 151, 107710.(SCI, JCR Q1)

  18. Jia-Li Wang, Tao Xu, Zhi-Long Chen*, et al. Synthesis and photophysical properties of symmetrical tetraaryltetranaphtho[2,3]porphyrin derivatives. Dyes and Pigments, 2024, 230, 112362. (SCI, JCR Q1)

  19. Ying Jiang, Yi-Jia Yan, Yomen Atassi, Zhi-Long Chen*, et al. Synthesis and evaluation of new tetrapyrrole derivatives with photodynamic anti-tumor effects. Dyes and Pigments, 2024, 230, 112360.  (SCI, JCR Q1)

  20. Hong-Yu Liang, Zhi-Long Chen*, et al. Synthesis and evaluation of novel meso-tetraphenyltetrabenzoporphyrins for photodynamic therapy, ACS Medicinal Chemistry Letters, 2024, 15(7): 1109-1117. (SCI, JCR Q2)

  21. Hong-Yu Liang, Yi-Jia Yan, Zhi-Long Chen*, et al. Preparation and pharmacological evaluation of A3B-typetetraphenyltetrabenzoporphyrins for photodynamic anti-tumor therapy.Journal of Photochemistry & Photobiology, A: Chemistry, 2024, 455, 115759.  (SCI, JCR Q2)

  22. E. Kogan, Zhi-Long Chen, I. Reshetov, et al. Polycationic photosensitizers as effective anticancer agents that destroy cancer stem cells, cancer vascularization and induce protective desmoplastic reaction around lung cancers. Photonics, 2024, 11(6), 485. (SCI, JCR Q3)

  23. T. Namulinda, Yijia Yan, D. Margetic, Zhi-Long Chen*, et al. Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates. Nanomedicine. 2024, 19(18-20): 1643-1658.(SCI, JCR Q2)

  24. T. Namulinda, Justus Kwetegyeka, Yomen Atassi, Zhi-Long Chen*, et al. pH-responsive Photinia glabra–zinc oxide–protoporphyrin IX nanoconjugates with enhanced cellular uptake for photodynamic therapy towards cancer cells. Nanomedicine, 2023, 19(2): 127-143. (SCI, JCR Q2)

  25. T. Namulinda, Zhi-Long Chen*, et al. Antibacterial and anticancer activities of green synthesized silver nanoparticles using Photinia glabra fruit extract. Nanomedicine, 2023, 18, (14): 987-1002. (SCI, JCR Q2)

  26. J. Wu, Zhilong Chen, et al. The use of multidimensional nomial logistic model and structural equation model in the validation of the 14-item health-literacy scale in Chinese patients living with type 2 diabetes. Risk Management and Healthcare Policy, 2023, 16，1567-1579.（SCI, JCR Q2）

  27. J. Wu, Zhilong Chen*, et al. Self-efficacy as moderator and mediator between medication beliefs and adherence in elderly patients with type 2 diabetes. Patient Preference and Adherence, 2023, 17, 217-226. (SCI, JCR Q3)

  28. Manyi Li, ZhiLong Chen*, et al. The bromoporphyrins as promising anti-tumor photosensitizers in vitro. Photochemical & Photobiological Sciences, 2023, 22, 427-439. (SCI, JCR Q3)

  29. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new fluorinated pyropheophorbide-a derivatives for photodynamic therapy. Dyes and Pigments, 2022, 197, 109932.( SCI, JCR Q1)

  30. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new pyropheophorbide-a derivatives for CAIX-targeted photodynamic therapy. Dyes and Pigments, 2022, 203,110328. (SCI, JCR Q1)

  31. Manyi Li, Zhi Long Chen*, et al, The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy. Journal of Cancer Research and Clinical Oncology, 2022, 148, 2335-2346. (SCI, JCR Q2)

  32. R. Matshitse, Zhi-Long Chen, T. Nyokong, et al. Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102705.  (SCI, JCR Q3)

  33. F. Sajjad, Zhi-Long Chen*, et al. Incorporation of green emission polymer dots into pyropheophorbide-α enhance the PDT effect andbiocompatibility. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102562. (SCI, JCR Q3)

  34. Manyi Li, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of novel fluorinated hematoporphyrin ether derivatives for photodynamic therapy. Bioorganic Chemistry, 2021, 107, 104528. (SCI, JCR Q1)

  35. F.Sajjad, Zhi-Long Chen*, et al. Synthesis and invitro PDT evaluation of red emission polymer dots (R-CPDs) and pyropheophorbide-α conjugates. Scientific Reports. 2021, 11, 10013. (SCI, JCR Q2)

  36. Zhuo Wu, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities. Bioorganic Chemistry, 2020, 101, 104042. (SCI, JCR Q1)

  37. Ying-Hua Gao, Zhi-Long Chen*. Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma. European Journal of Medicinal Chemistry, 2020,189, 112049.(SCI, JCR Q1)

  38. Ying-Hua Gao, Zhi-Long Chen*, Synthesis and evaluation of novel chlorophyll a derivatives as potent photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2020, 187, 111959. (SCI, JCR Q1)

  39. Ying-Hua Gao, V. Lovrekovic, Zhi-Long Chen*, et al. The photodynamic activities of dimethyl 131-[2-(guanidinyl)ethylamino] chlorin e6 photosensitizers in A549 tumor. European Journal of Medicinal Chemistry, 2019, 177, 144-152. (SCI, JCR Q1)

  40. Zhuo Wu, Yi-Jia Yan, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of AT1 receptor blockers derived from 6-substituted aminocarbonyl benzimidazoles. European Journal of Medicinal Chemistry, 2019,181,111553. (SCI, JCR Q1) 

  41. Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al. Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity. European Journal of Medicinal Chemistry, 2018, 160, 146-156. (SCI, JCR Q1)

著作：

  1. Akmaral Kussayeva, Zhilong Chen, Davor Margetić*，Synthesis of Pheophorbide a and Chlorin e6Photosentisizers, In：Photosensitizers and their Applications. Page 129-154. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. July 27, 2022. ISBN: 978-1-68507-880-5.

  2. Yi-Jia Yan, Danye Chen, Davor Margetić*, Zhi-Long Chen*. Photosensitizers and their Applications in China. In: Photosensitizers and their Applications. Page 155-192. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York, July 27, 2022. ISBN: 978-1-68507-880-5.

  3. Ronald N. Warrener, Davor Margetic, David A. Mann, Zhi-Long Chen, and Douglas N. Butler. Novel geometry polynorbornane scaffolds for chromophore linkage and spacing. Artificial Photosynthesis: From Basic to Industrial Application. Page 147-166. November 2005. Edited by Anthony F. Collings and Christa Critchley. Wiley-Verlag GmbH & Co. KgaA, Weinheim. ISBN: 3-527-31090-8.

  4. 张黎明，陈志龙主编。《常见海洋生物伤防治指南》，第二军医大学出版社，2002年。

  5. 姜成华，陈志龙主译。《防化医学手册》，第二军医大学出版社，2001年。

  6. 蔡建明，张建敏，陈志龙主编。《“三防”救治手册》，2001年10月。

专利：

申请国家发明专利90余项。

主要学术兼职：

为中国光学会激光医学分会常务委员；上海药学会理事；上海生化药物专业委员会副主任委员；上海药物化学专业委员会委员；上海药学会产学研创新工作委员会委员；上海市药学会医院药学专委会委员；上海药理学会治疗药物监测研究专委会委员；上海市抗癌协会肿瘤药学专委会委员；上海市医院协会临床药事管理专委会委员；上海市医学会第六届医疗事故鉴定专家库成员；上海市医学会第四届预防接种异常反应鉴定专家库成员。

为国家科学技术奖励评审专家；科技部重大重点专项评审专家；国家自然科学基金评审专家；教育部计划项目与博士点基金评审专家；上海市科委项目评审专家。

国际交流与合作：

与英国帝国理工学院（Imperial College of London, UK）、利物浦大学（The University of Liverpool, UK）；爱尔兰都柏林大学(University College Dublin, Ireland)；爱尔兰皇家外科学院(Royal College of Surgeons in Ireland, Ireland)；澳大利亚中昆士兰大学（Central Queensland University, Australia）；克罗地亚鲁德尔博斯科维奇研究所(Rudjer Bošković Institute, Croatia) ；俄罗斯科学院（Institute of Russian Academy of Sciences, Russia）；俄罗斯莫斯科国立第一医科大学(The First Moscow State Medical University, Russia)；南非罗德斯大学(Rhodes University, South Africa)；巴西圣保罗大学（University of Sao Paulo,Brazil）；埃及德曼胡尔大学（Damanhour University, Egypt）等多所大学与研究所有合作关系。

其它：

  1. 研究团队: 团队成员30余名，含博士助手2名、化学与生物医学博士后2名、博士硕士研究生二十余名、留学生6名。

  2. 博士后招聘：招收药学、化学、生物学、医学、材料学等专业博士后。

  3. 博士、硕士研究生招生：在化学、生物化学与分子生物学、生物与医药、生物医学工程、材料学等专业的博士、硕士点，招收药学、化学、生物学、医学、材料学等专业背景研究生。

电话：021-67792654；E-mail：zhlchen@dhu.edu.cn; zlchen1967@qq.com


Prof. Zhi-Long Chen

Brief Introduction:

Zhi-Long Chen got his B.Sc. and Ph.D. of Medicinal Chemistry from Second Military Medical University in 1996. He once worked as postdoctoral fellow in Shanghai Institute of Organic Chemistry, Chinese Academy of Science (China); in Central Queensland University (Australia) and the University of Liverpool (England). Prof. Chen has published more than 370 papers and 5 academic books, applied more than 90 patents. His projects were supported by more than 100 grants from Chinese Government and Shanghai Governments. More than 20 products were prepared and used in market.

He is the leader of Group of Pharmaceutical Science and Technology and as distinguished professor.

Research interests:

  1. The discovery of new drug based on artificial intelligence (AI) and computer-aided drug design (CADD).

  2. The discovery and development of new photosensitizer drugs in photodynamic therapy, and photo-diagnosis to tumor, bacteria-related infection disease, port-wine stains, etc.

  3. The discovery and development of new targeted drugs, including new anti-tumor drugs，new antihypertensive drugs and new molecular targeted drugs (such as folic acid, peptides, monoclonal antibodies targeted drug, etc.).

  4. The discovery of targeted nano drug delivery system with multi-function and multimodal effects.

  5. The discovery of new drugs from natural products.

  6. Studies on the pharmacology, toxicology, pharmacokinetics and mechanism of new drugs.

  7. The discovery of new medical imaging agents.  

Awards:

  1.  “Shanghai Pujiang Talents” in 2008 from Shanghai Science and Technology Bureau.

  2.  “Shanghai Outstanding Science and Technology Group Leader” in 2014 from Shanghai Science and Technology Bureau.

  3. Zhi-Long Chen, Wen-Hui Chen, Yi-Jia Yan, etc. “Studies on the discovery of new photodynamic drugs and reagents, on the fundamental research and application of photodynamic therapy” got the awards from Shanghai Pharmacy Association in 2012.

  4. Zhi-Long Chen, Wen-Hui Chen, Yi-Jia Yan, etc. “Studies on the discovery of new photodynamic drugs and reagents, on the fundamental research and application of photodynamic therapy” got the awards from Chinese Pharmacy Association in 2013.

  5. Xiu-Li Wang, Zhi-Long Chen, Heng Gu, etc. “The key technic innovations and their application of photodynamic therapy in skin diseases” got the award from Chinese Medicine Association in 2017.

  6. The first prize of “Innovation and Entrepreneurship Competition of Pinghu city” in 2018.

Main scientific research projects:

As group leader, his group has more than 100 projects supported by Chinese central government and Shanghai city government and other city governments. Such as 2 National Key R&D Program of China, 7 talent funds, 12 National Natural Science Fundation of China, 1 military medical and health key project, 15 projects from the grant of Shanghai Municipal Science and Technology Commission, and 16 international cooperation projects. Some of the projects listed as follows:

  1. Grant from National Key R&D Program of China（No. 2025YFE0101400; 2026YFE0204500）

  2. Grants from National Natural Science Foundation of China (No. 30271534；29872055；30973611；30070862； 21372042； 21977016；22361132541; et al).

  3. Grant from “Shanghai Outstanding Science and Technology Group Leader” programme（No.15XD1523400)

  4. Grant from “Shanghai Pujiang Talent” programme（No. 06PJ14001）.

  5. The key grants from Shanghai government (No. 064319020; 10DZ0502300; 13431900700；14140903500； 15411960400；17431902600；21430730100, etc.)

  6. International collaboration grant from Ministry of Science and Technology of China, and Shanghai government (No. 6-11、11BA1400700、13430722300、17430711900、18430713000、20490740400、21430730100、9-33、10-6、25HB2711400, etc.)

  7. Military Medical and Health Major Project (No. 01L054).

  8. Shanghai Education Commission Key Project Fund (No.: 10ZZ45).

  9. Key Project from the Ministry of Education of China (No. 108146).

Publications:

  1. Yao Yin, Sami Karam, Zhi-Long Chen*, et al. Discovery of novel 1,2,4-triazoles derivatives acting as NF1 activators against cervical cancer. Bioorganic and Medicinal Chemistry, 2026, 138, 118661. (SCI, JCR Q2)

  2. E. V Akhlyustina*, Zhi-Long Chen, I. V Reshetov, et al. Photophysical properties of photosensitizers based on polycationic phthalocyanines and their phototoxicity against breast cancer cells. Optical and Quantum Electronics, 2026, 58, 88, 1-11.   (SCI, JCR Q1)

  3. Ying Jiang, Igor V. Reshetov, Zhi-Long Chen*, et al. The synthesis, photophysical and biological properties of 5,10,15,20-tetra(4-substituted phenyl)tetrabenzoporphyrin derivatives. European Journal of Medicinal Chemistry, 2025, 291, 117612. (SCI, JCR Q1)

  4. Le Mi, Tao Xu, T. Nyokong, Zhi-Long Chen*, et al. Tetracationic tetraaryltetranaphtho[2,3]porphyrins for photodynamic inactivation against Staphylococcus aureus biofilm. European Journal of Medicinal Chemistry, 2025, 290, 117558. (SCI, JCR Q1)

  5. Yingyuan Peng, Sami Karam, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance. European Journal of Medicinal Chemistry, 2025, 282, 117090.  (SCI, JCR Q1)

  6. Ziyu Wang, Yingyuan Peng, Zhilong Chen*, et al. MiRNAbased drugs: Challenges and delivery strategies. Applied Microbiology and Biotechnology, 2025, 109:247. (SCI, JCR Q1)

  7. W.M. Eldehna, R. Elrayess, Zhi-Long Chen, et al. Discovery of novel piperidinyl-based benzoxazole derivatives as anticancer agents targeting VEGFR-2 and c-met kinases. Pharmaceuticals, 2025, 18, 1875. (SCI, JCR Q1).

  8. Mingjie Wang, V. S. Bagnato, T. Nyokong, Zhi Long Chen*, et al. Bis-quaternary ammonium BODIPY derivatives: Photophysical, antimicrobial, and antitumor photodynamic applications. Bioorganic Chemistry, 2025, 165, 108982. (SCI, JCR Q1)

  9. Feng Xiao, S. K. Bussadori, C. E. Palavecino,Zhi-Long Chen*. Synthesis and evaluation of multi-quaternary ammonium cation-functionalized BODIPYs with photodynamic antibacterial effects. Bioorganic Chemistry, 2025, 164,108859. (SCI, JCR Q1)

  10. Hongyu Liang, Yijia Yan, Zhi-Long Chen*, et al. Synthesis of novel meso-tetraphenyltetrabenzoporphyrins and evaluation of their photodynamic anticancer activities. ACS Omega, 2025, 10, 11119-11127. (SCI, JCR Q2)

  11. Anita Benić, Yijia Yan, Zhi-Long Chen*, Davor Margetic*, et al. Significant tumor inhibition of trimethyl-152-[L-aspartyl]pheophorbide a in tumor photodynamic therapy. ChemMedChem, 2025, e202500087 (1 - 10). (SCI, JCR Q2)

  12. Gennady Meerovich, E. Kogan, Zhi-Long Chen, I. Reshetov, et al Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience. Photodiagnosis and Photodynamic Therapy, 2025, 51, 104447. (SCI, JCR Q3)

  13. Tao Xu, I. Reshetov, E. A. Kogan, Zhi-Long Chen*, et al. Quaternary ammonium cations conjugated 5,15-diaryltetranaphtho [2,3] porphyrins as photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 267, 116228. (SCI, JCR Q1)

  14. Tao Xu, Le Mi, Zhi-Long Chen*, et al. Design, synthesis, and evaluation of 5,15- diaryltetranaphtho [2,3] porphyrins as photosensitizers in real-time photodynamic therapy and photodiagnosis. European Journal of Medicinal Chemistry, 2024, 264, 115980.  (SCI, JCR Q1)

  15. Ning Cao, Zhi-Long Chen*, et al. Synthesis and evaluation of novelmeso-substitutedphenyldithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 264,116012. (SCI, JCR Q1)

  16. Ning Cao, Zhi-Long Chen*, et al. Synthesis and photodynamic activity of novel thieno[3,2–b]thiophene fused BODIPYs with good bio-solubility and anti-aggregation effect. Bioorganic Chemistry, 2024, 143, 107097. (SCI, JCR Q1).

  17. Le Mi, G.A. Meerovich, I. V. Reshetov, E. A. Kogan, Yomen Atassi, Zhi-Long Chen*. Synthesis and evaluation of 5,15-diaryltetrabenzoporphyrins as photosensitizers for photo-diagnosis and photodynamic activity of tumors. Bioorganic Chemistry, 2024, 151, 107710.(SCI, JCR Q1)

  18. Jia-Li Wang, Tao Xu, Zhi-Long Chen*, et al. Synthesis and photophysical properties of symmetrical tetraaryltetranaphtho[2,3]porphyrin derivatives. Dyes and Pigments, 2024, 230, 112362. (SCI, JCR Q1)

  19. Ying Jiang, Yomen Atassi, Zhi-Long Chen*, et al. Synthesis and evaluation of new tetrapyrrole derivatives with photodynamic anti-tumor effects. Dyes and Pigments, 2024, 230, 112360.  (SCI, JCR Q1)

  20. Hong-Yu Liang, Ying Jiang,Zhi-Long Chen*, et al. Synthesis and evaluation of novel meso-tetraphenyltetrabenzoporphyrins for photodynamic therapy, ACS Medicinal Chemistry Letters, 2024, 15(7): 1109-1117. (SCI, JCR Q2)

  21. Hong-Yu Liang, Yi-Jia Yan, Zhi-Long Chen*, et al. Preparation and pharmacological evaluation of A3B-typetetraphenyltetrabenzoporphyrins for photodynamic anti-tumor therapy.Journal of Photochemistry & Photobiology, A: Chemistry, 2024, 455, 115759.  (SCI, JCR Q2)

  22. E. Kogan, Zhi-Long Chen, I. Reshetov, et al. Polycationic photosensitizers as effective anticancer agents that destroy cancer stem cells, cancer vascularization and induce protective desmoplastic reaction around lung cancers. Photonics, 2024, 11(6), 485. (SCI, JCR Q3)

  23. T. Namulinda, Yijia Yan, D. Margetic, Zhi-Long Chen*, et al. Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates. Nanomedicine. 2024, 19(18-20): 1643-1658.(SCI, JCR Q2)

  24. T. Namulinda, J. Kwetegyeka, Y. Atassi, S. Karam, Zhi-Long Chen*, et al. pH-responsive Photinia glabra–zinc oxide–protoporphyrin IX nanoconjugates with enhanced cellular uptake for photodynamic therapy towards cancer cells. Nanomedicine, 2023, 19(2): 127-143. (SCI, JCR Q2)

  25. T. Namulinda, Zhi-Long Chen*, et al. Antibacterial and anticancer activities of green synthesized silver nanoparticles using Photinia glabra fruit extract. Nanomedicine, 2023, 18, (14): 987-1002. (SCI, JCR Q2)

  26. J. Wu, Zhilong Chen, et al. The use of multidimensional nomial logistic model and structural equation model in the validation of the 14-item health-literacy scale in Chinese patients living with type 2 diabetes. Risk Management and Healthcare Policy, 2023, 16，1567-1579.（SCI, JCR Q2）

  27. J. Wu, Zhilong Chen*, et al. Self-efficacy as moderator and mediator between medication beliefs and adherence in elderly patients with type 2 diabetes. Patient Preference and Adherence, 2023, 17, 217-226. (SCI, JCR Q3)

  28. Manyi Li, ZhiLong Chen*, et al. The bromoporphyrins as promising anti-tumor photosensitizers in vitro. Photochemical & Photobiological Sciences, 2023, 22, 427-439. (SCI, JCR Q3)

  29. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new fluorinated pyropheophorbide-a derivatives for photodynamic therapy. Dyes and Pigments, 2022, 197, 109932.( SCI, JCR Q1)

  30. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new pyropheophorbide-a derivatives for CAIX-targeted photodynamic therapy. Dyes and Pigments, 2022, 203,110328. (SCI, JCR Q1)

  31. Manyi Li, Zhi Long Chen*, et al, The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy. Journal of Cancer Research and Clinical Oncology, 2022, 148, 2335-2346. (SCI, JCR Q2)

  32. R. Matshitse, Zhi-Long Chen, T. Nyokong, et al. Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102705.  (SCI, JCR Q3)

  33. F. Sajjad, Zhi-Long Chen*, et al. Incorporation of green emission polymer dots into pyropheophorbide-α enhance the PDT effect andbiocompatibility. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102562. (SCI, JCR Q3)

  34. Manyi Li, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of novel fluorinated hematoporphyrin ether derivatives for photodynamic therapy. Bioorganic Chemistry, 2021, 107, 104528. (SCI, JCR Q1)

  35. F.Sajjad, Zhi-Long Chen*, et al. Synthesis and invitro PDT evaluation of red emission polymer dots (R-CPDs) and pyropheophorbide-α conjugates. Scientific Reports. 2021, 11, 10013. (SCI, JCR Q2)

  36. Zhuo Wu, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities. Bioorganic Chemistry, 2020, 101, 104042. (SCI, JCR Q1)

  37. Ying-Hua Gao, Zhi-Long Chen*. Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma. European Journal of Medicinal Chemistry, 2020,189, 112049.(SCI, JCR Q1)

  38. Ying-Hua Gao, Zhi-Long Chen*, Synthesis and evaluation of novel chlorophyll a derivatives as potent photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2020, 187, 111959. (SCI, JCR Q1)

  39. Ying-Hua Gao, V. Lovrekovic, Zhi-Long Chen*, et al. The photodynamic activities of dimethyl 131-[2-(guanidinyl)ethylamino] chlorin e6 photosensitizers in A549 tumor. European Journal of Medicinal Chemistry, 2019, 177, 144-152. (SCI, JCR Q1)

  40. Zhuo Wu, Yi-Jia Yan, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of AT1 receptor blockers derived from 6-substituted aminocarbonyl benzimidazoles. European Journal of Medicinal Chemistry, 2019,181,111553. (SCI, JCR Q1) 

  41. Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al. Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity. European Journal of Medicinal Chemistry, 2018, 160, 146-156. (SCI, JCR Q1)

Books:

  1. Akmaral Kussayeva, Zhilong Chen, Davor Margetić*，Synthesis of Pheophorbide a and Chlorin e6Photosentisizers, In：Photosensitizers and their Applications. Page 129-154. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. 2022. July 27, 2022. ISBN: 978-1-68507-880-5.

  2. Yi-Jia Yan, Danye Chen, Davor Margetić*, Zhi-Long Chen*. Photosensitizers and their Applications in China. In: Photosensitizers and their Applications. Page 155-192. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. 2022. Publication Date: July 27, 2022. ISBN: 978-1-68507-880-5.

  3. Ronald N. Warrener, Davor Margetic, David A. Mann, Zhi-Long Chen, and Douglas N. Butler. Novel Geometry Polynorbornane Scaffolds for Chromophore Linkage and Spacing. Artificial Photosynthesis: From Basic to Industrial Application. Page 147-166. November 2005. Edited by Anthony F. Collings and Christa Critchley. Copyright @ 2005 Wiley-Verlag GmbH & Co. KgaA, Weinheim. ISBN: 3-527-31090-8.

  4. Li-Ming Zhang, Zhi-Long Chen as chief editor. Guidelines for the Prevention and Treatment of Common Marine Biological Injuries, Published by Second Military Medical University Publishers, 2002.

  5. Cheng-Hua Jiang, Zhi-Long Chen as main translator. Handbook of Preventive Medicine, Published by Second Military Medical University Publishers, 2001.

  6. Jian-Ming Cai, Jian-Min Zhang, and Zhi-Long Chen. "Three Prevention and Treatment Manual", 2001.

Patents:

More than 90 national invention patents have been applied.

Academic positions:

Prof. Zhi-Long Chen serves as committee member of Shanghai Association of Medicinal Chemistry, Shanghai Association of Pharmacy; committee member of Chinese Association of Laser Medicine; committee member of Shanghai Hospital Pharmacy Association; committee member of Therapeutic Drug Monitoring Research Committee of Shanghai Pharmacological Society; Committee of Shanghai Anti-Cancer Association and Clinical Pharmacy Management Committee of Shanghai Hospital Association; the member of Expert Pool for Shanghai Medical Association; the member of Medical Accident Appraisal and Identification of Abnormal Reactions to Vaccination of Shanghai Medical Association. Expert in the evaluation of major key projects of the Ministry of Science and Technology; Expert in the evaluation of the National Natural Science Foundation of China; Expert in the evaluation of the Ministry of Education's Program and Doctoral Program Fund; Expert in project evaluation from the Shanghai Municipal Commission of Science and Technology.

International Collaboration:

We have collaborations with scholars from UK (Imperial college of London; The University of Liverpool); Ireland (University College Dublin; Royal College of Surgeons in Ireland); Australia (Central Queensland University); Croatia (Rudjer Bošković Institute), Russia (Institute of Russian Academy of Sciences;The First Moscow State Medical University), South Africa (Rhodes University,University of South Africa),Brazil (University of Sao Paulo),Egypt (Damanhour University), et al. These cooperations were supported by grants from Chinese central government and Shanghai city government.

Others:

Team:

We have a team more than 30 persons, including 2 assistants of PhD, 2 postdoctors, 8 Ph.D students and 14 Master students, 5 international students, 7 technicians.

Labs:

We have more than 300 m2 organic chemistry labs and biological labs in the University and 300 m2 outside the University.

Position Opportunity:

    We accept students to our group to finish their Master degree and Ph. D..

  Postdoctoral research fellows and visiting scholars are also welcome.

Connecting Information:

E-mail: zlchen1967@qq.com; zhlchen@dhu.edu.cn;

Phone: 0086-21-67792654;

Address：Room 4110，Building 4, 2999 North Songjiang Renmin Road, Songjiang District, Shanghai, China. Postcode: 201620