个人简介
沈明武，东华大学生物与医学工程学院，研究员，博士生导师。2001年毕业于清华大学，获工学博士。2008年回国前，在美国密歇根大学历任访问学者和副研究员。
研究方向
基于功能化树状大分子的纳米医学，新型高分子载体系统的设计与构建以及有机/无机杂化纳米材料的肿瘤诊疗应用。
荣誉及获奖情况
2000年中国高校科学技术奖一等奖，2001年国家自然科学奖二等奖，2010年高校科学研究优秀成果奖自然科学奖一等奖，2016年中国医疗保健国际交流促进会华夏医学科技奖二等奖，2017年中华医学科技奖三等奖，2017年上海市科技进步奖一等奖，2018年上海市自然科学奖一等奖。
主持与承担主要项目情况
主持项目包括国家自然基金青年基金和主任基金各1项，上海市科委国际合作项目4项。
发表论著和授权专利情况
发表SCI收录期刊论文240余篇，论文引用超过12600余次，H-index为64；授权中国发明专利34项。
主要学术论文（2017-2022代表作）
1. Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827
2. Xin Li#, Lingxi Xing#, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combinational therapy. Acta Biomater.2017, 62, 273-283
3. Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374-385
4. Xiaoying Xu#, Lingzhou Zhao#, Xin Li, Peng Wang, Jinhua Zhao,* Xiangyang Shi*, Mingwu Shen*. Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles. Biomater. Sci.2017, 5, 2393-2397
5. Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146-6154
6. Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*.Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, 47, 1874-1900
7. Yong Hu,# Ruizhi Wang,# Yiwei Zhou,# Nuo Yu, Zhigang Chen, Dongmei Gao,* Xiangyang Shi,* Mingwu Shen*. Targeted dual-mode imaging and phototherapy of tumors using ICG-loaded multifunctional MWCNTs as a versatile platform. J. Mater. Chem. B2018, 6, 6122 - 6132
8. Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci.2018, 5, 1801612
9. Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J.2019, 362, 842-850
10. Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*.Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221
11. Xiaoying Xu, Kang Liu,Yue Wang, Changchang Zhang, Menghan Shi,Peng Wang, Linghong Shen, Jindong Xia,* Ling Ye,* Xiangyang Shi,*Mingwu Shen*. AMultifunctional Low-Generation Dendrimer-Based Nanoprobe for the Targeted Dual Mode MR/CT Imaging of Orthotopic Brain Gliomas. J. Mater. Chem. B2019, 7, 3639-3643
12. Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci.2019, 6, 1901800
13. Wei Zhu, Lingzhou Zhao, Yu Fan, Jinhua Zhao*, Xiangyang Shi*, Mingwu Shen*. 131I-Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging-Guided Radiotherapy of Tumors. Adv. Healthcare Mater.2019, 8, 1901299
14. Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117
15. Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen*, Xiangyang Shi*. Targeted Combination of Antioxidative and Anti-Inflammatory Therapy of Rheumatoid Arthritis Using Multifunctional Dendrimer-Entrapped Gold Nanoparticles as a Platform. Small2020, 16, 2005661.
16. Zhijun Ouyang, Du Li, Zhijuan Xiong, Cong Song, Yue Gao, Renna Liu, Mingwu Shen*, Xiangyang Shi*. Antifouling dendrimer-entrapped copper sulfide nanoparticles enable photoacoustic imaging-guided targeted combination therapy of tumors and tumor metastasis. ACS Appl. Mater. Interfaces2021, 13, 6069-6080.
17. Liang Jia, Xin Li, Hui Liu, Jindong Xia, Xiangyang Shi*, Mingwu Shen*. Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles. Nano Today2021, 36, 101022.
18. Yue Gao, Zhijun Ouyang, Chao Yang, Cong Song, Chunjuan Jiang, Shaoli Song, Mingwu Shen*, and Xiangyang Shi*. Overcoming T Cell Exhaustion Via Immune Checkpoint Modulation with a Dendrimer-Based Hybrid Nanocomplex. Adv. Healthcare Mater.2021, 10, 2100833.
19. Dayuan Wang, Liang Chen, Yue Gao, Cong Song, Zhijun Ouyang, Changsheng Li, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*, Mingwu Shen*. Impact of molecular rigidity on the gene delivery efficiency of core-shell tecto dendrimers. J. Mater. Chem. B2021, 9, 6149-6154.
20. Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Adv. Sci.2021, 8, 2100165.
21. Yue Gao, Xiangyang Shi and Mingwu Shen*. Intelligent Design of Ultrasmall Iron Oxide Nanoparticle-Based Theranostics. ACS Appl. Mater. Interfaces2021, 13, 45119-45129.
22. Cong Song, Zhijun Ouyang, Yue Gao, Honghua Guo, Shunjuan Wang, Dayuan Wang, Jindong Xia, Mingwu Shen*Xiangyang Shi*. Modular Design of Multifunctional Core-Shell Tecto Dendrimers Complexed with Copper(II) for MR Imaging-Guided Chemodynamic Therapy of Orthotopic Glioma. Nano Today2021, 41, 101325.
23. Yunqi Guo, Yu Fan, Gaoming Li, Zhiqiang Wang, Xiangyang Shi*, Mingwu Shen*. “Cluster bomb” based on redox-responsive carbon dot nanoclusters coated with cell membranes for enhanced tumor theranostics. ACS Appl. Mater. Interfaces2021, 13, 55815-55826.
24. Jingchao Li#, Xiangrong Yu#, Xiangyang Shi,*Mingwu Shen* Cancer nanomedicine based on polyethylenimine-mediated multifunctional nanosystems. Prog. Mater. Sci.2022, 124, 100871.
25. Rui Yang, Yue Gao, Zhijun Ouyang, Xiangyang Shi*, and Mingwu Shen*. Gold Nanostar-Based Complexes Applied for Cancer Theranostics. VIEW2022, DOI: 10.1002/VIW.20200171.
26. Yunqi Guo, Zhiqiang Wang, Xiangyang Shi*, and Mingwu Shen*. Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics. Exploration2022, DOI: 10.1002/EXP.20210171.
27. Wenjing Ma, Yue Gao, Zhijun Ouyang, Yu Fan, Hongwei Yu, Mengsi Zhan, Han Wang, Xiangyang Shi*, and Mingwu Shen*. Apoptosis-Enhanced Ferroptosis Therapy of Pancreatic Carcinoma through PAMAM Dendrimer-Iron(III) Complex-Based Plasmid Delivery. Sci. China Chem. 2022, DOI: 10.1007/s11426-021-1191-3.
28. Beilei Zhang, Yue Gao, Rui Yang, Zhijun Ouyang, Hongwei Yu, Han Wang, Xiangyang Shi*, and Mingwu Shen*. Tumor-Anchoring Drug-Loaded Fibrous Microspheres for MR Imaging-Guided Local Chemotherapy and Metastasis Inhibition. Adv. Fiber Mater.2022, DOI: 10.1007/s42765-022-00137-8.
其他信息
国际交流与合作：美国密歇根大学、葡萄牙马德拉大学、匈牙利徳布勒森大学、以色列巴伊兰大学、波兰罗茨大学、土耳其海峡大学、白俄罗斯国家科学院生物物理与细胞工程研究所。
主讲课程：
本科生课程：《生物数据处理与分析》、《生物医学工程导论》。
博士后和研究生招生信息：
欢迎感兴趣的具有化学、化工、生物医学、材料、纺织等相关研究背景的博士生申请博士后研究职位，同时欢迎感兴趣的具有相同背景的本科生和硕士生报考加入本课题组。
联系方式
E-mail: mwshen@dhu.edu.cn
