博士，东华大学生物与医学工程学院副教授。2005年中国科学院上海生命科学研究院取得博士学位。先后在中国科学院上海生命科学研究院、美国贝勒医学院（Baylor College of Medicine）生物化学与分子生物学系作博士后研究。2011年入选上海市浦江人才计划。主要从事药物（化学）遗传及细胞脂质代谢分子调控机制研究。在药用化合物作用机制、耐药性和功能基因遗传网络机制研究方面取的一系列研究成果，在Nat. Methods, PLOS Genet.，Cell Rep.，Mol. Cell.等学术刊物上发表论文100余篇，主持相关科研项目20余项。是中国生物化学与分子生物学会、中国细胞生物学学会、上海市生物化学与分子生物学学会会员，中国科学院西北高原生物研究所客座研究员。曾邀为Int. J. Mol. Sci.，Front. Microbiol.，Toxicol. Res.，FEBS Lett.，PLOS One，Exp. Ther. Med.等期刊审稿。
主要研究方向：
1.真菌耐药性分子机制及新治疗策略研究：临床化疗、导管、插管和器官移植等引起的条件性真菌感染增多，真菌耐药性问题日益严重，本方向目的是研究真菌的耐药机制并寻找新型抗真菌药物或新的治疗措施；
2. 脂肪积累调控的生理与分子机制研究：肥胖相关的脂代谢障碍引起脂肪肝、糖尿病、心脏衰竭等代谢综合症，严重危害公众的健康。通过建立“肥胖”细胞模型，研究脂肪积累调控的分子机制寻找有效的干预措施(减肥药物)及机制；
3.热点小分子药物的分子靶点鉴定及细胞调控机制研究：药用小分子化合物的分子靶点是药物产生药效(包括副作用)的基础，一些化合物如鬼臼毒素、氯碘喹啉等有明确的抑制肿瘤、缓解关节炎的临床治疗作用，但也有机制不明的严重副作用，本方向目的是研究一些热点药物的分子靶点明确作用机制，提出副作用消除策略。
申请专利
1) 一种TAG代谢障碍型肥胖酵母模型的构建方法，专利号: ZL201310016430.8
2) 一种检测活体酵母细胞UPR水平的双荧光素酶监测质粒及其构建和应用，专利号: ZL 201410333939.X
3) 一种抗肿瘤活性化合物鬼臼毒素PPT的前药及其制备方法，公开号：
4) 一种酿酒酵母等位基因高效整合质粒系统及其应用，公开号：105602983A
5) 一种基于毛细管电泳的细胞内的5-氟胞嘧啶和5-氟尿嘧啶的检测方法，公开号：107228895A
6) MRS6基因在提高烟草对重金属镉的耐受性中的应用. 申请号/受理号: 201810125591.3；公开号：108486144A
代表性论文(* 通讯作者)：1) M Li, P Zhu, Z Huang*, Y Huang, X Lv, Q Zheng, Z Zhu, Z Fan, Y Yang*, P Shi*. Aspirin damages the cell wall of Saccharomyces cerevisiae by inhibiting the expression and activity of dolichol-phosphate mannose synthase. FEBS Lett. 2022, 596(3):369-380.
2) Z Huang*, H Dai, X Zhang, Q Wang, J Sun, Y Deng, P Shi. BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae. Cell. Microbiol. 2021 Sep 5:e13391.https://doi.org/10.1111/cmi.13391
3) Y Kong, Q Wang, F Cao, X Zhang, Z Fang, P Shi, H Wang, Y Shen & Z Huang*. BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae, Free Radical Res., 2020, 54(4): 231-243，
4) X Zhang, X Kuang, F Cao, R Chen, Z Fang, W Liu*, P Shi, H Wang, Y Shen, Z Huang*. Effect of cadmium on mRNA mistranslation in Saccharomyces cerevisiae. J Basic Microbiol. 2020, 60(4): 372-379
5) R Chen, Q Zhu, Z Fang, Z Huang*, J Sun, M Peng, P Shi. Aluminum induces oxidative damage in Saccharomyces cerevisia. Can J Microbiol., 2020, 66(12): 713-722.
6) Z Huang*, Y Yu, Z Fang, Y Deng, Y Shen and P Shi. OLE1 reduces cadmium-induced oxidative damage in Saccharomyces cerevisiae. FEMS Microbiol. Lett., 2018, 365, doi: 10.1093/femsle/fny193
7) Q Wang, X Du, K Ma, P Shi, W Liu, J Sun, M Peng, Z Huang*. A critical role for very long-chain fatty acid elongases in oleic acid-mediated Saccharomyces cerevisiae cytotoxicity. Microbiol. Res., 2018, 201: 1-7.
8) Z Yang, Q Wang, K Ma, P Shi, W Liu, Z Huang*. Fluconazole inhibits the cellular ergosterol synthesis to confer synergism to berberine against yeast cells. J. Glob. Antimicrob. Resist., 2018, 13: 125-130.
9) Liu Y, Zhu P, Z Huang*, Zhou L, Shi P*. Simultaneous detection of 5-fluorocytosine and 5-fluorouracil in human cells carrying CD/5-FC suicide gene system by using capillary zone electrophoresis. J. Chromatogr. B., 2018, 1076: 1-7.
10) C Yan, S Wang, J Wang, H Li, Z Huang, S J un, M Peng, W Liu, P Shi. Clioquinol induces G2/M cell cycle arrest through the up-regulation of TDH
11) Z Fang, Z Chen, S Wang, P Shi*, Y Shen, Y Zhang, J Xiao and Z Huang*. Overexpression of OLE1 enhances cytoplasmic membrane stability and confers resistance to cadmium in Saccharomyces cerevisiae. Appl. Environ. Microb.,2017. 83(1): e02319-16.
12) Z Fang, W Liu, P Shi, Y Zhang, Z Huang*. Protective effect of berberine on the intestinal caecum in chicks with Eimeria tenella. Avian Biol. Res., 2016，9 (5)：235-239.
13) Z Huang*, L Wang, L Chen, Y Zhang, P Shi. Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. Acta Pharmaceut., 2015，65：463–471.
14) X Kuang, Z Fang, S Wang, P Shi*, Z Huang*. Effects of cadmium on intracellular cation homoeostasis in the yeast Saccharomyces cerevisiae.Toxico Enviro Chemt., 2015，97（7）：922-930.
15) Z Fang, X Kuang, Y Zhang, P Shi, Z Huang*. Anovel HAC1-based dual-luciferase reporter vector for detecting endoplasmic reticulum stress and unfolded protein response in yeast Saccharomyces cerevisiae, Plasmid,2015, 79, 48–53.
16) Z Fang, M Zhao, H Zhen, L Chen, P Shi, Z Huang*. Genotoxicity of tri- and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro. PLoS One. 2014, 11;9(8):e103194.
17) Z Fang, S Wang, X Du, P Shi, Z Huang*. Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.Acta Biol. Hung.,2014.65 (4)：481-492.
18) Z Huang, Z Fang , H Zhen , L Zhou, HM Amin , P Shi. Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma. Leuk Lymphoma. 2014, 55(8):1876-83.
19) Z Huang, K Chen, J Zhang, Y Li, H Wang, D Cui, J Tang, Y Liu, X Shi, W Li, D Liu, R Chen, RS. Sucgang, X Pan. A Functional Variomics Tool for Discovering Drug-Resistance Genes and Drug Targets.Cell Reports, 2013, 3(2): 577-585.
20) Z Huang, S. Srinivasan, JH Zhang, KF Chen,YX Li, W Li, FA Quiocho, and X Pan. Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLoS Genet., 2012，8(11): e1003083. doi:10.1371.
21) Z Huang, K Chen, T Xu, J Zhang, Y Li, W Li, A Agarwal, A Clark, J Phillips, and X Pan. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryot. cell, 2011，10(11):1536-44.
22) X Pan, S Reissman, NR Douglas, Z Huang, DS Yuan, X Wang, JM McCaffery, J Frydman and JD Boeke. Trivalent Arsenic Inhibits the Functions of Chaperonin Complex. Genetics,2010, 186(2):725-34.
23) Z Huang, G Chen, P Shi. Effects of emodin on the gene expression profiling of human breast carcinoma cells. Cancer Detect. Pre.,2009, 32: 286-291.
24) J Zhang, X Shi , Y Li , BJ Kim , J Jia , Z Huang , T Yang , X Fu , SY Jung , Y Wang , P Zhang , ST Kim, X Pan, J Qin. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.Mol. Cell.,2008, 11;31(1):143-51.
25) Z Huang, RS Sucgang, Y Lin, X Shi, JD Boeke & X Pan. Plasmid-chromosome shuffling for non-deletion alleles in yeast. Nat. Methods., 2008 Feb;5(2):167-9.
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