张珂

发布部门：生物与医学工程学院 发布时间：2024-11-28


个人简介

张珂，博士，中国科学院上海免疫与感染研究所研究员。2012年于中国科学院微生物研究所获得博士学位，2013年至2021年于美国德克萨斯大学西南医学中心进行博士后研究。目前发表SCI论文20余篇。主持国家自然科学基金1项、国家自然科学基金专项项目2项。


研究方向

  1. 病毒感染与RNA生物学

  2. 抗病毒药物研发


荣誉及获奖情况

  1. 上海市白玉兰人才计划—2023年

  2. 上海市浦江人才—2022年


主持与承担主要项目情况

  1. 国家自然科学基金“A型流感病毒mRNA出核转运分子机制的研究”，主持；

  2. 国家自然基金委专项“抗猴痘病毒miRNA药物的筛选、鉴定及机制研究”，主持；

  3. 国家自然基金委专项“新型冠状病毒病抑制宿主mRNA出核转运的分子机制研究”，主持；



发表论著情况


(1) Jiayin Guo, Yaru Zhu, Xiaoya Ma, Guijun Shang, Bo Liu* and Ke Zhang*. (2023) Virus Infection and mRNA Nuclear Export. Int. J. Mol. Sci. 24(16): 12593. (Co-Corresponding Author)

(2) Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lina, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang*, and Lei Sun*. (2023) SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1. Autophagy. https://doi.org/ 10.1080/15548627.2023.2238579. (Co-Corresponding Author)

(3) Ke Zhang, Lisa Miorin, Tadashi Makio, Ishmael Dehghan, Shengyan Gao, Yihu Xie, Hualin Zhong, Matthew Esparza, Boning Gao, John D. Minna, Zhijian Chen, Adolfo García-Sastre, Yi Ren, Richard W. Wozniak, Beatriz M.A. Fontoura. (2021) Nsp1 Protein of SARS-CoV-2 Disrupts the mRNA Export Machinery to Inhibit Host Gene Expression. Science Advances 7(6):eabe7386.

(4) Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S Patel, Anastasija Cupic, Tadashi Makio, Menghan Mei, Oded Danziger, Elena Moreno, Kris M White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo-Gomez, Ignacio Mena, Xin Yin, Laura Martin-Sancho, Nevan J Krogan, Sumit K Chanda, Michael Schotsaert, Richard W Wozniak, Yi Ren, Brad R Rosenberg, Beatriz M A Fontoura, Adolfo García-Sastre. (2020) SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. Proc. Natl. Acad. Sci. 117(45):28344-28354.

(5) Ke Zhang#, Yihu Xie#, Raquel Muñoz-Moreno, Juan Wang, Liang Zhang, Matthew Esparza, Adolfo García-Sastre, Beatriz M.A. Fontoura, Yi Ren. (2019) Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export. Nature Microbiology. 4(10):1671-1679. (Co-First Author)

(6) Ke Zhang, Guijun Shang, Abhilash Padavannil, Juan Wang, Ramanavelan Sakthivel, Xiang Chen, Min Kim, Matthew G Thompson, Adolfo García-Sastre, Kristen W Lynch, Zhijian J Chen, Yuh Min Chook, Beatriz MA Fontoura. (2018) Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. 115(52):E12218-E12227.

(7) Ke Zhang#, Zhao Wang#, Guizhang Fan, Juan Wang, Shengyan Gao, Yun Li, Lei Sun, Changcheng Yin, Wenjun Liu. (2015) Two polar residues within C- terminal domain of M1 are critical for the formation of influenza A Virions. Cellular Microbiology 17(11): 1583-93. (Co-First Author)

(8) Ke Zhang, Zhao Wang, Xiaoling Liu, Changcheng Yin, Zeshan Basit, Bin Xia, Wenjun Liu. (2012) Dissection of Influenza A Virus M1 Protein: pH-Dependent oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain. PLoS ONE 7(5): e37786.


联系方式

Email：kzhang6@siii.cas.cn 

办公地址：上海市徐汇区岳阳路320号新生命科学大楼B705