苏枭

发布部门：生物与医学工程学院 发布时间：2024-06-12

个人简介

苏枭，博士，中国科学院特聘研究岗位（二级研究员），博士生导师。2004年获复旦大学和美国UCSF联合培养博士学位；2004-2007美国UCSF博士后；2007-2012美国UIC助理研究教授和UCSF副研究员；2012年担任呼吸道感染免疫课题组组长。主持国家自然基金重点项目、重大项目集成重点、重点专项、国家自然基金重大培育和面上项目（多项）；上海市基础重点；承担国家重点研发计划和中国科学院先导B项目等。现任上海市肺部炎症和损伤重点实验室副主任、上海市免疫学感染免疫专业委员会委员、牛津大学出版社QJM杂志（IF14）常务副主编, Mol Med副主编等。在Nature Med、Lancet、JCI、Cell Discovery等杂志发表论文100多篇，引用率6200多次。


研究方向

  1. 肺炎症损伤和修复神经调控机制

  2. 感觉神经元识别肺内病原和应答的神经环路


荣誉及获奖情况

  1. 获得美国Parker B. Francis肺生物医学奖

  2. 美国NIH Ruth L. Kirschstein奖

  3. 市级科技进步一等奖等


主持与承担主要项目情况

  1. 国家自然科学基金（重点专项）：靶向神经元治疗急性肺损伤，主持；

  2. 国家重点研发计划：移植后继发感染的关键机制及临床诊治新策略研究，骨干


发表论著情况

    1. Zhao C, Chen J, Liu Z, Liang H, Chen X, Cheng L, Xie S, Lin Z, Wu R, Zhao Q, Xue Y, Lai X, Jin X, Xu J and Su X*. Activation of nicotinic acetylcholine receptor α7 subunit limits ZIKV infection via promoting autophagy and ferroptosis. Molecular Therapy 2024 May 30:S1525-0016(24)00339-3. doi: 10.1016/j.ymthe.2024.05.037.

    2. Chen X, Zhang C, Wei T, Chen J, Pan T, Li M, Wang L, Song J, Chen C, Zhang Y, Song Y, Su X*. Activation of α7nAChR in AT2 promotes alveolar regeneration through WNT7B signaling in acute lung injury. JCI Insight2023 Aug 8;8(15):e162547. doi: 10.1172/jci.insight.162547.

    3. Chen J, Lai X, Song Y and Su X*. Neuro-immune Recognition and Regulation in the Respiratory System. European Respiratory Review2024; 0: 240008 [DOI: 10.1183/16000617.0008-2024].

    4. Du J, Liu Y, Lan G, Zhou Y, Ni Y, Liao K, Zheng F, Cheng Q, Shi G, Su X*. PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation. Cell Death Dis. 2023 Jul 15;14(7):432. doi: 10.1038/s41419-023-05971-1.

    5. Zhao C, Pan M, Chen C, Wei D, Li L, Jiang Y, Zhang Y, Liu W, Zhang X, Matthay MA, Wang H, Jin X, Xu J and Su X*. Cholinergic-α7 nicotinic acetylcholine receptor signaling promotes influenza replication. J Med Virology 2024.

    6. Liu L, Zhang DY, Xu JY, Dai HP, Tang N, Su X, Cao B. SARS-CoV-2 viral sepsis: from bedside to bench. Lancet. 2020 May 9;395(10235):1517-1520. doi: 10.1016/S0140-6736(20)30920-X.

    7. Huang X, Hao S, Liu J, Huang Y, Liu M, Xiao C, Wang Y, Pei S, Yu T, Xu J, Wang H, Dai D, Su X*, Xiao Y*. The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. Cell Mol Immunol. 2021 Apr;18(4):969-978. doi: 10.1038/s41423-021-00660-5.

    8. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA*, Su X* Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Cell Discov. 2017 Apr 11;3:17009. doi: 10.1038/celldisc.2017.9. eCollection 2017.

    9. Zhao CQ, Chen J, Cheng LP, Xu KF, Yang YY*, and Su X*. Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells. Emerg Microbes Infect. 2020 Dec;9(1):691-706. doi: 10.1080/22221751.2020.1742585.

    10. Zhang C, Zhao CQ, Chen XY, Tao RJ, Meng GX, Liu X, Shao CZ*, Su X*. Induction of ASC pyroptosis requires gasdermin or caspase-1/11-dependent mediators and IFN-β from pyroptotic macrophages to Stem Cells. Cell Death Dis. 2020 Jun 18;11(6):470. doi: 10.1038/s41419-020-2664-0.

    11. Wen J, Sun J, Tang Y, Zhao J, Su X*. Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells. J Mol Cell Biol. 2023 Jul 25:mjad048. doi: 10.1093/jmcb/mjad048.

    12. Song S, Zhao C, Wen J, Chen J, Lin Z, Xie S, Qi H, Wang J, SuX*. Vagal-mAChR4 signaling promotes MuLV/Friend‐induced acute erythroleukemia. Virologica Sinica. 2023, Doi: 10.1016/j.virs.2023.05.005

    13. Di CX, Jiang YS, Li LL, Qiu WN, Shi MM, Zhu YG, Zhang J, Song YL, Su X*, Qu JM*. ASCs activate cGAS-type I IFNs-IL-7 axis via Pseudomonas aeruginosa-derived outer membrane vesicles to resolve pneumonia. Stem Cells. 2023, DOI: 10.1093/stmcls/sxad016

    14. Li N, Chen J, Xie S, Zhang M, Shi T, He Y, Jie Z*, Su X*. Oral antibiotics relieve allergic asthma in post-weaning mice via reducing iNKT cells and function of ADRB2. Front Immunol. 2022 Oct 25;13:1024235. doi: 10.3389/fimmu.2022.1024235. eCollection 2022.

    15. Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi, H Wang J, Su X*. Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. Cell Insight, 2022 June 2022；1 (3): 100028.doi.org/10.1016/j.cellin.2022.100028.

    16. Gao ZW, Li L, Huang YY, Zhao CQ, Xue SJ, Chen J, Yang ZZ, Xu JF*, Su X*. Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. Acta Pharmacol Sin. 2021 Jan 7. doi: 10.1038/s41401-020-00579-z.

    17. Feng XT, Zhao CQ, Li L, Feng JJ, He W, Shi TY, Li N, Jie ZJ*, Su X*. iNKT cells with high PLZF expression are recruited into the lung via CCL21-CCR7 signaling to facilitate the development of asthma tolerance in mice.Eur J Immunol. 2020 Jul 26. doi: 10.1002/eji.202048798.

    18. Chen XY, Zhao CQ, Zhang CP, Li QM, Chen J, Cheng LP, Zhou J, Su X*, Song YL* Vagal-α7nAChR signaling promotes lung stem cell regeneration via fibroblast growth factor 10 during lung injury repair.Stem Cell Res Ther. 2020 Jun 10;11(1):230. doi: 10.1186/s13287-020-01757-w.

    19. Chen XY, Chen J, Song YL*, Su X*. Vagal α7nAChR signaling regulates α7nAChR+Sca1+ cells during lung injury repair.Stem Cell Res Ther. 2020 Aug 31;11(1):375. doi: 10.1186/s13287-020-01892-4.

    20. Zhang H, Xue K, Li W, Yang X, Gou Y, Su X, Qian F, Sun L. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Nat Commun. 2024 Jan 4;15(1):252. doi: 10.1038/s41467-023-44168-0

    21. Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Aug 24. doi: 10.1038/s41590-021-01010-3.


联系方式

Email：xsu@siii.cas.cn 

办公地址：上海市岳阳路320生命科学研究大楼B609