个人简介
刘博，中国科学院上海免疫与感染研究所研究员，课题组长，博士生导师。本科毕业于复旦大学，中国科学院生物化学与细胞生物学研究所博士，美国加州大学伯克利分校博士后、副研究员。以通讯作者身份在Nature、NatureCommunications、Journal of Experimental Medicine等权威期刊发表论文，工作被Nature Reviews Immunology、Journal of Cell Biology等期刊撰文点评。入选上海市“海外高层次人才”、上海市“浦江人才”等,中国免疫学会青年工作委员会委员。
研究方向
核酸免疫识别受体的转运和功能调节机制
感染和自身免疫病进程中的固有免疫和炎症失调
荣誉及获奖情况
主持与承担主要项目情况
获得国家自然科学基金委面上项目、中国科学院上海分院青年攀登计划、上海市“科技创新行动计划”、上海市科技重大专项、上海市浦江人才等项目支持。
代表性论文
Rael, V.; Yano, J.; Huizar, J.; Slayden, L.; Weiss, M.; Turcotte, E.; Terry, J.; Zuo, E.; Thiffault, I.; Pastinen, T.; Farrow, E.; Jenkins, J.; Becker, M.; Wong, S.; Stevens, A.; Otten, C.; Allenspach, E.; Bonner, D.; Bernstein, J.; Wheeler, M.; Saxton, R.; Network, U.; Liu, B.*; Majer, O.*; Barton, G.* Large scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans. Journal of Experimental Medicine, 2024, 221(8): e20232005.
Ni, H.; Wang, Y.; Yao, K.; Wang, L.; Huang, J.; Xiao, Y.; Chen, H.; Liu, B.*; Yang, C.*; Zhao, J.* Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Nature Communications, 2024, 15(1): 1-17.
Guo, J.; Zhu, Y.; Ma, X.; Shang, G.; Liu, B.*; Zhang, K.* Virus Infection and mRNA Nuclear Export. International Journal of Molecular Sciences, 2023, 24(16): 12593.
Lind, N.#; Rael, V.#; Pestal, K.#; Liu, B.; Barton, G. Regulation of nucleic acid-sensing Toll-like receptors. Nature Reviews Immunology, 2022, 22(4): 224-235.
Majer, O.#; Liu, B.#,*; Kreuk, L.; Krogan, N.; Barton, G.* Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity. Nature, 2019, 575: 366-370.
Majer, O.; Liu, B.; Woo, B.; Kreuk, L.; Van Dis, E.; Barton, G. Release from Unc93b1 in endosomes reinforces the compartmentalized activation of select nucleic acid-sensing TLRs. Nature, 2019, 575: 371-374.
Majer, O.; Liu, B.; Barton, G. Nucleic acid-sensing TLRs: trafficking and regulation. Current Opinion in Immunology, 2017, 44: 26-33.
Mardaryev, A.; Liu, B.; Rapisarda, V.; Poterlowicz, K.; Malashchuk, I.; Rudolf, J.; Sharov, A.; Jahoda, C.; Fessing, M.; Benitah, S.; Xu, G.; Botchkarev, V. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology, 2016, 212(1): 77-89.
Liu, B.#; Liu, Y.#; Du, Y.; Mardaryev, A.; Yang, W.; Chen, H.; Xu, Z.; Xu, C.; Zhang, X.; Botchkarev, V.; Zhang, Y.; Xu, G. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development, 2013, 140: 780-788.
Liu, B.; Lin, Y.; Darwanto, A.; Song, X.; Xu, G.; Zhang, K. Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. Journal of Biological Chemistry, 2009, 284: 32288-32295.
联系方式
Email：bliu@ips.ac.cn
办公地址：徐汇区岳阳路320号新生命科学楼B-615