酒亚明

发布部门：生物与医学工程学院 发布时间：2024-06-12

个人简介

酒亚明，博士生导师，国家优青，中科院百人（终期评估优秀），中国细胞生物学学会细胞结构与细胞行为分会副会长，European Journal of Cell Biology杂志副主编。致力于研究病原感染条件下宿主细胞和免疫细胞信号应答、亚细胞结构动态重构的病理功能及抗感染研究，发表SCI论文五十余篇，包括PNAS、Nature Communications、EMBO J, Journal of Cell Biology、Current Biology、Nano Letters、Science Bulletin、Current Opinion in Cell Biology等，筛选鉴定靶向宿主亚细胞重构的广谱抗感染小分子药物并申请专利3项。


研究方向

  1. 从微观角度研究细胞骨架的动态性及对细胞结构和行为的调控等生理功能

  2. 从宿主细胞角度研究其在感染条件下的动态应答和致病机制等病理功能

  3. 从病原体角度研究不同病原（新发突发多发）感染天然宿主细胞和免疫细胞的完整连贯完成过程

  4. 相关光学显微成像技术和探针的新功能改进和新技术研发　


荣誉及获奖情况

  1. 上海市科技系统三八红旗手—2024年

  2. 中国细胞生物学会青年女科学家职业发展基金—2024年


主持与承担主要项目情况

  1. 国家自然科学基金（面上项目基金）：主持；

  2. 国家自然科学基金（重大研究计划培育项目基金）：主持；


发表论著情况


1. Zhao S#, Miao C#, Li Z#, Gao X#, Eriksson J*, Jiu Y* “Vimentin cage - a double-edged sword in host anti-infection defense”. Current Opinion in Cell Biology. Jan 2;86:102317. doi: 10.1016/j.ceb.2023.102317.  2024.

2. Huang X, Xing Y, Cui Y, Ji B, Ding B, Zhong J, Jiu Y* “Actomyosin dependent cell contractility orchestrates zika virus infection”. Journal of Cell Science. Aug 25:jcs.261301. doi: 10.1242/jcs.261301. 2023.

3. Zhang Y#, Zhang X#, Li Z#, Zhao W#, Yang H, Zhao S, Tang D, Zhang Q, Liu H, Li H, Li B, Lappalainen P, Cui Z*, Jiu Y* “Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion”. Science Bulletin.Aug 15. doi.: 10.1016/j.scib.2023.08.031. 2023.

4. Xing Y#, Chen R#, Li F#, Xu B, Han L, Jiu Y*, Zhong J*, Zhou G* “Discovery of a fused bicyclic derivative of 4-hydroxypyrrolidine and imidazolidinone as a new anti-HCV agent”.Virology. Jul 20. Doi: 10.1016/j.virol.2023.07.012. 2023.

5. Wang Y#, Liang H#, Liu Y#, Bao Q, Yang S, Xu X, Chen Y, Liu W, Shi X, Shi Y, Liu X, Liu B, Hao H*, Jiu Y*, Liu Y* “Lamin A/C and vimentin as a coordinated regulator during amoeboid migration in microscale confined microenvironments”. Nano Letters.Jul 17. doi: 10.1021/acs.nanolett.3c02096. 2023.

6. Zhao W#, Zhao S#, Han Z#, Ding X#, Hu G, Qu L, Huang Y, Wang X, Mao H, Jiu Y, Hu Y, Tan J, Ding X*, Chen L*, Guo C*, Li H* “Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging”. Nature Photonics. Jun 15. doi: 10.1038/s41566-023-01234-9. 2023.

7. Mei J#, Huang X#, Fan C#, Fang J, Jiu Y* “Cytoskeleton network participates in the anti-infection responses of macrophage”. BioEssays. May 31:e2200225. doi: 10.1002/bies.202200225. 2023.

8. Zhao S#, Xu Q#, Cui Y#, Yao S, Jin S, Zhang Q, Wen Z, Ruan H, Liang X, Chao Y, Sansonetti P, Wei K*, Tang H*, Jiu Y* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection”. Nature Communications.Jan 30;14(1):478. doi: 10.1038/s41467-023-36123-w. 2023.

9. Zhang Y#, Zhao S, Li Y, Feng F, Li M, Xue Y, Cui J, Xu T, Jin X*, Jiu Y* “Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication”. Proc Natl Acad Sci U S A. Feb 22;119(8):e2113909119. doi: 10.1073/pnas.2113909119. 2022.

10. Fan C#, Shi X, Zhao K, Wang L, Shi K, Liu Y, Li H, Ji B, Jiu Y* “Cell migration orchestrates migrasome formation by shaping retraction fibers” Journal of Cell Biology. Apr 4;221(4): e202109168. doi: 10.1083/jcb.202109168. 2022.封面论文，获年度十佳论文专题报道

11. Shi X#, Tang D#, Xing Y#, Zhao S, Fan C, Zhong J, Cui Y*, Shi K*, Jiu Y* “Actin nucleator formins regulate the tension-buffering function of caveolin-1” Journal of Molecular Cell Biology. Jan 29;13(12):876-888. doi: 10.1093/jmcb/mjab070. 2021.封面论文

12. Liu W#, Tang D#, Xu X, Liu Y*, Jiu Y* “How physical factors coordinate virus infection：a perspective from mechanobiology”. Frontiers in Bioengineering and Biotechnology. Oct 29;9:764516. doi: 10.3389/fbioe.2021.764516. 2021.

13. Shi X#, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y* “Feedback-driven mechanisms between phosphorylated caveolin-1 and contractile actin assemblies instruct persistent cell migration” Frontiers in Cell and Developmental Biology. Apr 12;9:665919. doi: 10.3389/fcell.2021.665919. 2021.

14. Wen G#, Li S, Wang L, Chen X, Sun Z, Liang Y, Jin X, Xing Y, Jiu Y, Tang Y, Li H* “High-fidelity structured illumination microscopy by point-spread-function engineering” Light: Science & Application. Apr 1;10(1):70. doi: 10.1038/s41377-021-00513-w. 2021.

15. Zhang Y#, Wen Z, Shi X, Liu Y, Eriksson J*, Jiu Y* “The diverse roles and dynamic rearrangement of vimentin during virus infection”. Journal of Cell Science. Nov 5;134(5):jcs250597. doi: 10.1242/jcs.250597. 2020.

16. Zhao S#, Shi X#, Zhang Y#, Wen Z, Cai J, Gao W, Xu J, Zheng Y, Ji B, Cui Y, Shi K, Liu Y, Li H, Jiu Y*, “Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers”. iScience. Apr 24;23(4):100975. doi: 10.1016/j.isci.2020.100975. 2020.

17. Wen Z#, Zhang Y#, Lin Z, Shi K, Jiu Y*, “Cytoskeleton - a crucial key in host cell for coronavirus infection”. Journal of Molecular Cell Biology. Dec;12(12):968-79. doi: 10.1093/jmcb/mjaa042. 2020.

18. Xing Y#, Wen Z#, Gao W, Lin Z, Zhong J, Jiu Y*, “Multifaceted functions of host cell caveolae/caveolin-1 in virus infections”. Viruses. Apr 26; 12(5):E487. doi: 10.3390/v12050487. 2020.

19. Kumari R#, Jiu Y, Carman P, Tojkander S, Kogan K, Varjosalo M, Gunning P, Dominguez R, Lappalainen P* “Tropomodulins control balance between protrusive and contractile structures in migrating cells by stabilizing actin-tropomyosin filaments”. Current Biology. Mar 9;30(5):767-778.e5. doi: 10.1016/j.cub.2019.12.049. 2020.

20. Zhao S#, Cai J#, Zhang X, Cui J, Jiu Y* “Different formins restrict localization of distinct tropomyosins on dorsal stress fibers in osteosarcoma cells”. Cytoskeleton (Hoboken). Jan;77(1-2):16-24. doi: 10.1002/cm.21588. 2020.

21. Jiu Y#*, Kumari R, Fenix A, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette D, Lappalainen P* “Myosin-18B promotes the assembly of myosin II stacks to drive maturation of contractile actomyosin bundles”. Current Biology. Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. 2019.

22. Shi X#, Zhao S, Cai J, Wong G, Jiu Y* “Active FHOD1 promotes the formation of functional actin stress fibers”. Biochemical Journal. Oct 30;476(20):2953-2963. doi: 10.1042/BCJ20190535. 2019.封面论文

23. Li J#, Gao W#, Zhang Y#, Cheng F, Eriksson J, Etienne-Manneville S, Jiu Y* “Engagement of vimentin intermediate filaments in hypotonic stress”. Journal of Cellular Biochemistry. Aug;120(8):13168-13176. doi: 10.1002/jcb.28591. 2019.

24. Deng L#, JiangW, Wang X, Merz A, Hiet M, ChenY, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G* “Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes”. Journal of Hepatology. Jul;71(1):52-61. doi: 10.1016/j.jhep.2019.03.006. 2019.

25. Li J#, Zou Y, Li Z, Jiu Y* “Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling”. Science China Life Sciences.  Oct;62(10):1368-1374. doi: 10.1007/s11427-018-9488-1. 2019. 

26. Zhang Y#, Gao W, Li J, Wu W, Jiu Y* “The role of host cytoskeleton in flavivirus infection”. Virologica Sinica. 2019 Feb;34(1):30-41. doi: 10.1007/s12250-019-00086-4. 2019. 封面论文

27. Liu X#, Salokas K, Tamene F, Jiu Y, Weldatsadik R, Varjosalo M* “An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations”. Nature Communications. Mar 22; 9(1):1188. doi: 10.1038/s41467-018-03523-2. 2018.

28. Jiu Y#*, Peranen J, Schaible N, Cheng F, Eriksson J, Krishnan R, Lappalainen P* “Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA”. Journal of Cell Science. Jan 18; 130(5): 892-902. doi: 10.1242/jcs.196881. 2017.

29. Jiu Y#, Lehtimaki J, Tojkander S, Cheng F, Jaalinoja H, Liu X, Varjosalo M, Eriksson J, Lappalainen P* “Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers”. Cell Reports. Jun 16; 11(10):1511-1518. doi: 10.1016/j.celrep.2015.05.008. 2015.

30. Weinheimer I#, Jiu Y#, Rajami M#, Matilainen O, Kallijarvi J, Cuellar W, Lu R, Saarma M, Holmberg C, Jantti J, Valkonen J* “Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants”. PLoS Pathogens. Mar 6; 11(3):e1004711. doi: 10.1371/journal.ppat.1004711. 2015.

31. Yu Y#, Wang L#, Jiu Y#, Zhan Y, Liu L, Xia Z, Song E, Xu P*, Xu T* “HID-1 is a novel player in the regulation of neuropeptide sorting”. Biochemical Journal. Feb 24; 434(3):383-390. doi: 10.1042/BJ20110027. 2011.

32. Jiu Y#, Yue Y#, Yang S#, Liu L, Yu J, Zhang R, Wu Z*, Xu T* “Insulin-like signaling pathway for decision making behavior in C. elegans”. Protein Cell. Jan;1(1):75-81. doi: 10.1007/s13238-010-0003-4. 2010.

33. Jiu Y#, Hu Z#, Liu J#, Wu Z*, Xu T* “α-LTX and α-LTXN4C induce [Ca2+]i elevation through different mechanisms in pancreatic β cells”. Chinese Science Bulletin. Jan; 51(2):158-163. doi: 10.1007/s11434-005-1029-5. 2006.

34.李剑，酒亚明*。中间纤维的功能和研究进展。中国细胞生物学学报，41(3). doi: 10.11844/cjcb.2019.03.0283. 2019 (特邀综述、40周年纪念专刊)


联系方式

Email：ymjiu@siii.cas.cn 

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