个人简介
戴阿光,理学博士,中国科学院上海免疫与感染研究所研究员。2014年于美国佛罗里达州立大学获得分子生物物理学博士学位,2014-2017年先后在美国FSU、Brandeis Univ.和Southwestern Medical Center进行博士后研究,并于2017-2020年任美国Univ. Of Texas at Austin冷冻电镜平台主任。目前发表论文7篇论文,授权中国发明专利1项,创建的电镜平台在世界上第一个获得新冠刺突蛋白冷冻电镜结构并应用到辉瑞和摩德纳等数个疫苗中,主持研究所十三五科教基础设施P2冷冻电镜平台建设。
研究方向
原位冷冻断层扫描成像技术在感染与免疫上的应用
冷冻电镜高分辨高通量技术研究
主持与承担主要项目情况
发表论著情况
1.Tang S; Li M; Chen L;Dai A; Liu Z; Wu M; Yang J; Hao H; Liang J; Zhou X; Qian Z.
Codelivery of SARS-CoV-2 Prefusion-Spike Protein with CBLB502 by a Dual-Chambered Ferritin Nanocarrier Potentiates Systemic and Mucosal Immunity. ACS Appl Bio Mater. 2022 Jul 18;5(7):3329-3337
2.Wang W;Wang Z; Yang X; Gao Y; Zhang X; Cao L;Dai A; Sun J; Sun L; Jiang L; Chen Z; Wang L.The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discov. 2021 Oct 19;7(1):94. doi: 10.1038/s41421-021-00324-8.
3.Long Gui; Kangkang Song; Douglas Trischler; Raqual Bower; Si Yan; Aguang Dai; Katherine Augspurger; Jason Sakizadeh; Magdalena Grzemska; Thomas Ni; Mary E. Porter* ; Daniela Nicastro* ; Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex, Proc Natl Acad Sci USA, 2019, 116(46): 23152-23162.
4.Aguang Dai; Feng Ye; Danne W. Taylor; Guiqing Hu; Mark H. Ginsberg* ; Kenneth A. Taylor* ; The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand, J Biol Chem, 2015, 290(45): 27168-27175.
5. Shuyu Liu# ; Jian He# ; Chiaho Shih; Kupeng Li; Aguang Dai; Z. Hong Zhou* ; Jingqiang Zhang* ; Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths, Virus Res., 2010, 149(2): 241-244. (4) Liu Shuyu# ; He Jian# ; Li Kunpeng; Dai Aguang; 6. Cai Changjie; Zhang Jingqiang* ; Three-dimensional structure of the hepatitis B core antigen particle truncated at residue 154, Sci China Life Sci, 2010, 54: 171-174. (期刊论文)
7. Zhihong Li; Jian He; Xiaojun Huang; Aguang Dai; Lingpeng Cheng; Dingyong Shao; Jingqiang Zhang* ; The truncated virus-like particles of C6/36 cell densovirus: implications for the assembly mechanism of brevidensovirus, Virus Res., 2008, 132(1-2): 248-252.
联系方式
Email:agdai@ips.ac.cn
办公地址:上海徐汇岳阳路320号生命科学实验楼B407