张赵文斌

发布部门：生物与医学工程学院 发布时间：2022-06-01


个人简介

张赵文斌，工学博士，东华大学生物与医学工程学院青年研究员。2022年，于中国科学院上海硅酸盐研究所获得博士学位，随后于2022年至2025年在中国科学院大学开展博士后研究工作。致力于开发面向不同病理环境的生物活性材料，涵盖中药-离子螯合材料、无机离子诱导的细胞外囊泡以及硅化改性纳米酶材料等。这些材料在组织修复与疾病治疗领域展现出广泛的应用潜力，例如烧伤治疗、雄激素性脱发的改善以及心肌梗死的康复等。目前以第一/通讯作者在Nature Communications、Science Advances、Advanced Science和Bioactive Materials等发表了20余篇SCI论文。主持了国家自然科学基金青年项目、国家资助博士后研究人员计划B档项目，并荣获博士后科研业绩评估考核资助二档及中国博士后科学基金面上资助等多项支持。


研究方向

  1. 病理微环境适配型生物活性材料设计。

  2. 生物活性材料的生物学修复机制研究。


荣誉及获奖情况

  1. 2024年度国家博士后科研业绩评估考核资助

  2. 2023年度国科温州研究院“优秀博士后”

  3. 2023年度温州医科大学“科研先进工作者”


参与承担主要项目情况

  1. 国家自然科学基金青年科学基金，含铜硅可降解纳米酶用于衰老皮肤创面修复的研究，主持；

  2. 国家资助博士后研究人员计划B档，铜-姜黄素螯合伤口敷料重建神经细胞供应源恢复烧伤皮肤感知系统，主持；

  3. 博士后基金面上资助，硅化磷酸氢铜用于衰老皮肤创面的愈合与康复研究，主持；

  4. 国家自然科学基金面上项目，超声响应型压电复合水凝胶诱导YAPhi平滑肌细胞调控斑块愈合的作用及机制研究，参与。


代表性学术论文（#代表共同第一作者*代表通讯作者）

  1. Zhaowenbin Zhang, et al. A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials. Advanced Science, 2024, 11(43): 2407718.

  2. Ping Sun#, Zhaowenbin Zhang#, et al. Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling. Science Advances, 2025, 11(15): eadr7208.

  3. Bin Yu#, Hekai Li#, Zhaowenbin Zhang#, et al. Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice, Nature Communications, 2023, 14, 2094.

  4. Tianwang Guan, Zhenxing Lu, Rundong Tai, Shuai Guo, Zhaowenbin Zhang*, et al. Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway. Bioactive Materials, 2025, 49: 378-398.

  5. Zhaowenbin Zhang, et al. CuCS/Cur composite wound dressings promote neuralized skin regeneration by rebuilding the nerve cell" factory" in deep skin burns. Materials Today Bio, 2024, 26, 101075.

  6. Zhaowenbin Zhang, et al. A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch, Bioactive Materials, 2023, 24, 81-95.

  7. Zhaowenbin Zhang, et al. Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing, Bioactive Materials, 2021, 6, 1910-1920.

  8. Zhaowenbin Zhang, et al. Design of a multifunctional biomaterial inspired by ancient chinese medicine for hair regeneration in burned skin, ACS Applied Materials & Interfaces, 2020, 12, 12489-12499.

  9. Zhaowenbin Zhang, et al. Curcumin/Fe-SiO2 nano composites with multi-synergistic effects for scar inhibition and hair follicle regeneration during burn wound healing, Applied Materials Today, 2021, 23, 101065.

  10. Na Sun#, Zhaowenbin Zhang#, et al. Enhanced activation of retinal progenitor cells by zinc silicate bioceramics for effective functional restoration in retinal degenerative diseases. View, 2025: 20240068.

  11. Fangzhou Chen#, Zhaowenbin Zhang#, et al. Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair. Biomaterials Research, 2025, 29: 0180.

  12. Yiru Xia#, Zhaowenbin Zhang#, et al. Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion. Regenerative Biomaterials, 2024, 11, rbae028.

  13. Yanping Feng#, Lefeng Su#, Zhaowenbin Zhang#, et al. pH-responsive wound dressing based on biodegradable cup nanozymes for treating infected and diabetic wounds. ACS Applied Materials & Interfaces, 2024, 16(1), 95–110.

  14. Ye Yuan#, Zhaowenbin Zhang#, et al. A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis, Bioactive Materials, 2023, 26, 264-278.

  15. Zhen-Xing Guo#, Zhaowenbin Zhang#, et al. A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis, Acta Biomaterialia, 2023, 157, 639-654.

  16. Jinfeng Xu#, Muhammad Rizwan Younis#, Zhaowenbin Zhang#, et al. Mild heat-assisted polydopamine/alginate hydrogel containing low-dose nanoselenium for facilitating infected wound healing, ACS Applied Materials & Interfaces, 2023, 15(6), 7841-7854.

  17. Jing Yu#, Yuze Xu#, Zhaowenbin Zhang#, et al. Strontium zinc silicate bioceramic composite electrospun fiber membrane for hair follicle regeneration in burn wounds, Composites Part B: Engineering, 2023, 110953.

  18. Liqin Cao#, Huiyao Gu#, Zhaowenbin Zhang#, et al. Calcium silicate/bortezomib combinatory therapy for multiple myeloma, Journal of Materials Chemistry B, 2023, 11(9), 1929-1939.

  19. Hua Yin#, Zhaowenbin Zhang#, et al. A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution, Journal of Materials Chemistry B, 2023, 11(38), 9163-9178.

  20. Yumei Que#, Jiaxin Shi#, Zhaowenbin Zhang#, et al. Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling, Exploration, 2023, 20230067.

  21. Tao Chen#, Zhaowenbin Zhang#, et al. Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics, Bioactive Materials, 2021, 6, 3194-3206.


联系方式

邮箱：zhangzhaowb@dhu.edu.cn